Panoptes VM is the industry’s first virtual metrology solution deployed in high-volume manufacturing fabs for real-time run-to-run control. Panoptes VM achieves the holy grail of machine learning algorithms - reliability, robustness, and scalability based on deep domain knowledge - while oblivious to the underlying customer data. It is highly accurate and reliable even under low sampling rates of very high-dimensional sensor data. It is robust against data drifts and shifts via time-aware normalization and adaptive online learning. It is scalable for many process and equipment types with an easy-to-use interface for process engineers.